Levodopa

Product Name	Levodopa
CAS	59-92-7
Melting point	276-278 °C (lit.)
Boiling point	34.28°C (rough estimate)
Density	1.3075 (rough estimate)
Storage conditions	2-8°C
Solubility	Stabilize
Morphological	Powder
Acidity coefficient (pKa)	2.32(at 25℃)
Color	Powder, Crystal
Purity	98%
Shelf life	2 years

Intro

Levodopa is the precursor of dopamine, is the international common drug name, different manufacturers have different trade names when the drug is listed. Oral levodopa tablets are generally dissolved in the stomach, then discharged into the duodenum, then into the small intestine, where they are absorbed into the blood. A small part of levodopa can eventually enter the brain through the “blood-brain barrier” and be taken up by neurons in the substantia nigra or other nerve cells. Under the action of dopa decarboxylase, a carboxyl group is removed to become dopamine. Thus, it can supplement the dopamine in the brain and reduce the symptoms of Parkinson’s disease.

Chemical property of Levodopa

White or white crystalline powder. Melting point 285.5℃ (decomposition). Soluble in dilute acid, slightly soluble in water, insoluble in ethanol, ethyl ether and dinestin chloroform. Odorless, tasteless, blackened in air.

Use of Levodopa

Levodopa is one of the effective drugs in the treatment of palsy tremor. It is one of the precursors for the synthesis of norepinephrine and dopamine in the body and belongs to catecholamine. Levodopa can enter the brain through the blood-brain barrier, and is converted into dopamine by dopamine decarboxylase. But the obvious effect is slow, the side effects are larger. Rat oral LD50>4000mg/kg.
An effective drug for the treatment of palsy tremor, mainly used in Parkinson’s syndrome.

Character

White powder; Gas is small, no bitterness.

Apply

Baisfu Levodopa can treat Parkinson’s disease and Parkinson’s syndrome. Treat hepatic coma, improve central function, make patients awake, improve symptoms. Promote sleep, reduce fat; Increase bone density and reverse osteoporosis; Increase muscle strength, enhance sexual ability.

Side reaction

Gastrointestinal reactions: In the treatment dose, about 80% of the early onset of nausea, loss of appetite, etc. This is because DA directly stimulates the gastrointestinal tract and excites the chemosensory area of the medulla to induce vomiting. Take after meals, slow down the rate of increment can be reduced. Or treat with domperidone (morbutyline).