Oleanolic acid

Product Name	Oleanolic acid
CAS	508-02-1
Melting point	>300 °C (lit.)
Boiling point	502.79°C (rough estimate)
Density	1.0261 (rough estimate)
Storage conditions	2-8°C
Solubility	Dissolved in methanol, solubility of 0.1g/mL, clarified
Morphological	Solid
Acidity coefficient (pKa)	2.52(at 25℃)
Color	Light yellow
Purity	98%
Shelf life	2 years

Intro of Oleanolic acid

Oleanolic acid is a pentacyclic triterpenoid compound extracted from the fruit of hydrocarpa hepatica or fructus ligustris of hydrocarpa family. Existing in a variety of plants as free bodies and glycosomes, oleanolic acid has become a commonly used liver protection drug in clinical practice. It has obvious protective effect on acute and chronic liver damage caused by carbon tetrachloride in rats, and can reduce elevated ALT and AST.

Inflammation, necrosis and interstitial inflammation are reduced, preventing the formation of fibrosis, promoting the regeneration of liver cells, and accelerating the recovery of dead tissue. Electron microscopy showed that enlarged mitochondria and rough endoplasmic reticulum recovered after oleanolic acid treatment. Its succinate can reduce the activity of P450 enzyme in mouse liver microsomal cells.

In addition, It can correct protein metabolism disorders, reduce inflammation, strengthen the heart, diuresis, increase white blood cells, reduce blood sugar, promote immune function, inhibit the growth of S-180 tumor strains and so on.

Physical and Chemical Properties

That exists widely in plants, with a general content of 0.2% to 2%. The content of cucurbitaceae is 1.5% ~ 2%, and the content of Ligustrum fruit is 0.6% ~ 0.7%. Oleanolic acid is a white acicular crystal (ethanol), odorless and tasteless. Unstable to acids and bases. Melting point 308 ~ 310℃, [α]20D+73.3° (c=0.15, chloroform), insoluble in water, soluble in methanol, ethanol, ether, acetone and chloroform.

The Role of Oleanolic Acid

1. This product has anti-inflammatory, sedative, cardiac, diuretic, lipid-lowering, blood-glucose lowering, liver protection and enzyme lowering, immune enhancement and inhibition of S180 tumor strain growth, and is an effective ingredient in the development of drugs for the treatment of liver disease and blood glucose lowering.
2. Baisfu Oleanolic acid has a protective effect on chromosome damage and a preventive effect on experimental atherosclerosis. It is clinically used to treat infectious acute jaundice hepatitis and chronic viral hepatitis. It has obvious effect of decreasing low pyrupium transaminase and yellowing.