Product Overview

Gypenosides represent the primary bioactive saponin compounds extracted from Gynostemma pentaphyllum, a climbing vine widely known as Jiaogulan or “Southern Ginseng,” which has earned its reputation as an immortality herb in traditional Chinese medicine. Specifically, gypenosides share remarkable structural similarities with the ginsenosides found in Panax ginseng, with several individual gypenoside molecules proving chemically identical to ginsenosides Rb1, Rb3, Rd, and F2. Moreover, Gynostemma pentaphyllum stands as the only plant outside the Panax genus known to contain these precious dammarane-type saponins. Consequently, dietary supplement formulators increasingly select our gypenosides as a cost-effective, sustainable alternative to Panax ginseng extracts that still delivers comparable adaptogenic and cardiometabolic benefits.

Our gypenosides extract originates from carefully cultivated Gynostemma pentaphyllum grown in the pristine mountainous regions of southern China, where the natural altitude and climate conditions maximize saponin accumulation in the aerial parts. Furthermore, we employ a gentle ethanol-water extraction followed by macroporous resin purification, which concentrates the total gypenosides to standardized levels without degrading the heat-sensitive saponin structures. Additionally, every batch undergoes HPLC fingerprinting to confirm the presence and ratio of key marker compounds including gypenoside XVII, gypenoside XLIX, and the ginsenoside-identical molecules. As a result, you receive a fully characterized, consistently potent ingredient that supports reproducible efficacy in your finished formulations across the dietary supplement, functional beverage, and cosmeceutical markets.

Key Specifications

Product Name	Gypenosides (Jiaogulan Saponin Extract)
Botanical Source	Gynostemma pentaphyllum (Thunb.) Makino (Cucurbitaceae)
Plant Part Used	Aerial parts (leaves and tender stems)
CAS Number	15588-68-8
Active Compounds	Gypenosides (dammarane-type triterpene saponins)
Total Gypenosides	20% / 40% / 80% / 98% (UV / HPLC)
Appearance	Light yellow-brown to brownish fine powder
Odor & Taste	Characteristic herbal aroma; slightly bitter, sweet aftertaste
Particle Size	98% through 80 mesh (customizable)
Solubility	Soluble in ethanol and aqueous ethanol; partially soluble in water
Loss on Drying	≤ 5.0%
Ash Content	≤ 5.0%
Heavy Metals	Pb ≤ 2.0 ppm, As ≤ 1.0 ppm, Cd ≤ 1.0 ppm, Hg ≤ 0.1 ppm
Pesticide Residues	Compliant with USP <561> and EU Regulation 396/2005
Microbiological	TPC ≤ 1,000 CFU/g; Yeast & Mold ≤ 100 CFU/g; E. coli negative; Salmonella negative/25g
Extraction Solvent	Ethanol-water (food-grade); residual ethanol ≤ 5,000 ppm
Shelf Life	24 months when stored below 25°C in sealed, light-protected containers
Packaging	1 kg / 5 kg / 25 kg aluminum foil vacuum-sealed bags in fiber drums

 

Health Benefits & Applications

1. Cardiovascular & Metabolic Health

Gypenosides demonstrate powerful cardioprotective effects through multiple complementary mechanisms. Specifically, clinical studies show that gypenosides activate AMPK and eNOS signaling pathways, which promote nitric oxide production and healthy vasodilation. Furthermore, gypenosides support healthy lipid profiles by upregulating LDL receptor expression and inhibiting HMG-CoA reductase activity, thereby reducing total cholesterol and triglyceride levels naturally. Additionally, research demonstrates that gypenosides improve insulin sensitivity and glucose uptake in skeletal muscle cells through AMPK-dependent mechanisms. Consequently, formulators incorporate our gypenosides into cardiovascular support formulas, metabolic health supplements, blood sugar management products, and comprehensive wellness stacks targeting the modern lifestyle diseases that affect hundreds of millions of consumers worldwide.

2. Adaptogenic Stress Response & Cognitive Function

Jiaogulan gypenosides function as premier adaptogens that help the body maintain homeostasis under physical, chemical, and psychological stress. Specifically, gypenosides modulate the hypothalamic-pituitary-adrenal (HPA) axis to normalize cortisol rhythms without over-suppressing the stress response. Moreover, animal and human studies demonstrate that gypenoside supplementation improves cognitive performance, enhances memory consolidation, and protects neurons from oxidative damage through upregulation of endogenous antioxidant enzymes including SOD and glutathione peroxidase. Additionally, gypenosides promote cerebral blood flow via eNOS activation, which supports mental clarity and focus during demanding cognitive tasks. As a result, nootropic and brain health brands increasingly select our gypenosides as a natural, plant-based cognitive enhancer that complements ingredients like lion’s mane, bacopa, and phosphatidylserine.

3. Antioxidant Defense & Anti-Aging

The antioxidant capacity of gypenosides extends far beyond direct free radical scavenging. Specifically, gypenosides activate the Nrf2/ARE pathway, which serves as the master regulator of the body’s endogenous antioxidant defense system. Furthermore, this pathway activation triggers the expression of over 200 cytoprotective genes, including catalase, heme oxygenase-1, and NAD(P)H quinone oxidoreductase, creating a sustained cellular protection network rather than a one-time antioxidant hit. Additionally, gypenosides protect mitochondrial DNA from oxidative damage and support mitochondrial biogenesis through PGC-1α activation. Consequently, anti-aging supplement brands, longevity-focused formulators, and cosmetic companies developing inside-out beauty products incorporate our gypenosides to deliver science-backed cellular rejuvenation benefits.

4. Immune Modulation & Anti-Inflammatory Support

Gypenosides modulate the immune system through a bidirectional regulatory mechanism that distinguishes them from simple immune stimulants or suppressants. Specifically, gypenosides balance Th1/Th2 immune responses, enhance natural killer cell activity during immune challenges, and simultaneously calm inappropriate inflammatory cascades through NF-κB pathway inhibition. Moreover, research demonstrates that gypenosides reduce the production of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β while preserving the body’s ability to mount appropriate immune defenses against pathogens. Additionally, gypenosides support gut immune function by maintaining intestinal barrier integrity and promoting a healthy microbiome composition. Thus, formulators leverage our gypenosides for immune resilience formulas, inflammatory response management products, and gut-immune axis support supplements targeting the growing consumer demand for holistic immune health solutions.

Why Choose Baisfu

Authentic Botanical Identity With DNA Verification

We authenticate every harvest of Gynostemma pentaphyllum through DNA barcoding and macroscopic botanical identification. Consequently, you never risk receiving adulterated material from morphologically similar but pharmacologically inferior Cucurbitaceae species that frequently contaminate the Jiaogulan supply chain.

Multi-Point HPLC Fingerprinting for Batch Consistency

Beyond simple total gypenoside quantification, we perform full HPLC fingerprint analysis on every batch to verify the presence and ratio of key individual gypenosides including gypenoside XVII, gypenoside XLIX, and the ginsenoside-identical compounds. Moreover, we provide comparative chromatograms against our reference standard, which ensures that your product delivers the same phytochemical profile batch after batch.

Gentle Ethanol-Water Extraction Preserves Heat-Sensitive Saponins

Our low-temperature ethanol-water extraction and macroporous resin purification process avoids the high temperatures that degrade dammarane-type saponins. As a result, the native molecular structures remain intact, which preserves both the bioavailability and the full spectrum of biological activities that your customers expect.

Customizable Standardization From 20% to 98%

We offer gypenosides at every major standardization level — 20%, 40%, 80%, and 98% total gypenosides — to match your specific formulation requirements and cost targets. Additionally, we provide custom blends with complementary Jiaogulan flavonoids and polysaccharides for brands seeking whole-herb spectrum formulations.

Comprehensive Safety Testing Above Pharmacopoeia Standards

We test every batch for over 200 pesticide residues, four heavy metals, aflatoxins, microbiological contaminants, and residual solvents. Furthermore, our testing program exceeds both USP and EU Pharmacopoeia requirements, which positions your products favorably for regulatory review in the most demanding global markets.

Regulatory Dossier Support for Global Registration

Our technical team provides complete documentation packages including botanical identification reports, extraction process descriptions, HPLC chromatograms, stability data, and safety test results. Consequently, this documentation supports your product registration under US FDA NDI notifications, EU Traditional Herbal Medicinal Product applications, Health Canada NPN licensing, and TGA listing.

Sustainable, Traceable Supply Chain

We maintain direct relationships with Gynostemma pentaphyllum farming cooperatives in designated cultivation zones, which provides full traceability from field to finished powder. Moreover, our contract farming program ensures fair compensation for growers while guaranteeing consistent raw material quality and availability.

Factory-Direct Pricing With No Minimum Order Penalties

Our vertically integrated production — from cultivation through extraction and final packaging — eliminates intermediary costs. Additionally, we maintain flexible minimum order quantities that accommodate both startup brands testing the market and established manufacturers requiring container-volume supply.

Quality Assurance

Our quality management system operates under ISO 9001:2015 certification with HACCP and GMP compliance throughout all production stages. Specifically, raw material acceptance includes botanical identity verification, macroscopic inspection, and preliminary TLC screening before any material enters the extraction facility. Furthermore, in-process quality checks monitor extraction efficiency, concentration ratios, and drying parameters in real time. Additionally, the final product undergoes full release testing including HPLC quantification, heavy metal analysis by ICP-MS, pesticide residue screening by GC-MS/MS and LC-MS/MS, microbiological testing per USP <61> and <62>, and residual solvent analysis. Moreover, we conduct accelerated stability studies at 40°C / 75% RH on every new specification before commercial release and retain retention samples from each batch for 36 months. Consequently, our gypenosides consistently meet specification and provide the quality documentation that supports your regulatory compliance and customer confidence.

Ordering & Contact

Minimum Order Quantity	1 kg (sample); 25 kg (commercial)
Lead Time	5–10 business days for stock specifications
Shipping Methods	Air freight, sea freight, or express courier (DHL/FedEx/UPS)
Payment Terms	T/T, L/C at sight, or trade assurance via Alibaba
Sample Policy	Free samples (10–50 g) available for qualified buyers
Custom Standardization	Available upon request — any gypenoside level from 20% to 98%