Berberine Hydrochloride CAS：633-65-8
-Plant extracts
- Berberine Hydrochloride Bulk Powder
- Berberine HCl Metabolic Health Supplement Ingredient
- Natural Berberis Aristata Extract Supplier
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Berberine Hydrochloride — Premium Plant-Derived Alkaloid for Metabolic, Cardiovascular, and Gut Health Formulations
Berberine Hydrochloride stands as the principal bioactive isoquinoline alkaloid extracted from the rhizomes, roots, and bark of several Berberis species, including Berberis aristata, Berberis vulgaris, and Coptis chinensis (Chinese goldthread). For more than 2,000 years, traditional medicine systems across China, India, and the Middle East have used these plants to support digestive comfort, blood sugar balance, and microbial defense. Today, modern clinical research fully validates these traditional applications, and Berberine Hydrochloride has become one of the most sought-after botanical actives in the global nutraceutical market. In addition, formulators continue to expand its use into functional foods, sports nutrition, pet supplements, and cosmeceutical applications.
Our Berberine Hydrochloride powder features ≥ 97% HPLC-verified purity, a bright yellow crystalline appearance, and full compliance with major international pharmacopoeia standards. We produce it at our ISO9001- and ISO14001-certified facility in Xi’an, China, and we ship it to brand owners, contract manufacturers, and distributors in more than 50 countries. As a result, partnering with Shaanxi Baisifu Biological Engineering gives you direct access to a stable, scalable, and competitively priced supply of one of the most versatile plant alkaloids on the market.
What Is Berberine Hydrochloride?
Berberine Hydrochloride belongs to the isoquinoline alkaloid family — a class of naturally occurring plant compounds that feature a quaternary nitrogen in their molecular architecture. Chemists first isolated berberine from Berberis vulgaris in 1830, and since then, researchers have published more than 5,000 peer-reviewed studies on its pharmacological activity. Furthermore, modern science confirms that Berberine Hydrochloride activates AMP-activated protein kinase (AMPK), supports healthy glucose uptake, modulates the gut microbiome, and influences lipid metabolism. Consequently, this single molecule addresses blood sugar balance, cardiovascular wellness, digestive health, and immune defense simultaneously — a rare combination that distinguishes it from single-action synthetic compounds.
Traditional medicine systems in China, India, and the Middle East have used Berberis and Coptis preparations for centuries to manage diarrhea, dysentery, eye infections, and metabolic imbalances. Modern pharmacological research now validates these traditional applications with rigorous in vitro, in vivo, and human clinical evidence. Therefore, Berberine Hydrochloride bridges the gap between ancestral herbal wisdom and contemporary evidence-based nutrition — a compelling narrative for brands marketing natural, science-backed metabolic health products.
Product Specifications
The table below summarizes the core technical parameters of our Berberine Hydrochloride powder:
| Parameter | Details |
| Product Name | Berberine Hydrochloride |
| Botanical Source | Berberis aristata / Coptis chinensis rhizome |
| Appearance | Bright yellow fine crystalline powder |
| Molecular Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 g/mol |
| Purity / Assay | ≥ 97% (HPLC verified); higher grades (98%, 99%) available |
| Melting Point | 145 °C (with decomposition) |
| Solubility | Slightly soluble in cold water; soluble in hot water, ethanol, methanol |
| Particle Size | Fine crystalline, 80–100 mesh standard |
| Loss on Drying | ≤ 5.0% |
| Heavy Metals | ≤ 10 ppm (complies with USP / EP standards) |
| Shelf Life | 24 months in sealed, light-protected packaging |
| Packaging | 1 kg / 5 kg / 25 kg fiber drums; custom packaging available |
| Storage Conditions | Cool, dry, dark place; room temperature acceptable |
| Certifications | ISO9001 / ISO14001 / KOSHER / HALAL |
Key Benefits and Biological Functions
Berberine Hydrochloride offers an extensive range of scientifically validated health benefits that fuel strong market and commercial demand. Beyond its classic metabolic and cardiovascular advantages that researchers have well documented, continuous clinical studies keep uncovering brand-new potentials in gut regulation, liver care and anti-aging longevity support. For this reason, the following functional advantages fully explain why global nutraceutical and functional food brands consistently select Berberine Hydrochloride as a core star ingredient in premium formulations.
Blood Sugar and Metabolic Support — First of all, Berberine Hydrochloride activates the AMPK pathway and enhances insulin sensitivity. It effectively stabilizes healthy fasting glucose, postprandial glucose and HbA1c levels. Multiple clinical trials prove that a daily intake of 500 mg, two to three times per day, delivers metabolic regulation effects that match metformin outcomes in certain populations.
Cardiovascular and Lipid Health — In addition, Berberine Hydrochloride lowers total cholesterol, LDL cholesterol and triglyceride levels while it optimizes healthy HDL cholesterol status. As a direct result, product formulators widely incorporate this ingredient in heart health supplements, weight management formulas and metabolic syndrome solutions.
Gut Microbiome Modulation — Furthermore, Berberine Hydrochloride boosts the proliferation of beneficial gut bacteria including Bifidobacterium and Akkermansia. It restrains harmful opportunistic pathogens and reinforces intestinal barrier integrity.Accordingly, it occupies a core position in modern gut health and digestive comfort product lines.
Antimicrobial and Immune Defense — Moreover, Berberine Hydrochloride delivers broad-spectrum inhibitory effects against bacteria, fungi, viruses and parasites. At the same time, it balances inflammatory responses by regulating NF-κB pathways and pro-inflammatory cytokines. This makes it a highly versatile ingredient for daily immune support.
Liver and Detoxification Support —Additionally, Berberine Hydrochloride maintains balanced liver enzyme levels. It reduces excessive hepatic fat deposition and protects liver cells from toxin-induced damage. Such unique properties perfectly fit consumer demands for liver detox and anti-aging longevity products.
Weight Management and Body Composition — Latest clinical trials confirm that Berberine Hydrochloride reduces body weight, BMI and waist circumference when users combine supplementation with healthy lifestyle adjustments. Besides that, it optimizes leptin sensitivity, curbs excessive appetite and controls food cravings for better body shape management.
Longevity and Cellular Health — Currently, emerging research reveals that Berberine Hydrochloride activates sirtuin longevity pathways and stimulates mitochondrial biogenesis.Hence, it perfectly fits the positioning of healthy aging and longevity-focused functional formulas.
Applications and Market Segments
Berberine Hydrochloride adapts to diverse finished product forms with excellent compatibility. Thanks to its outstanding safety profile, multi-target functional mechanisms and rising consumer awareness of metabolic health, formulators apply this ingredient widely in the following market segments:
Dietary Supplements — Brands integrate it into capsules, tablets, softgels and liquid extracts to develop targeted products for blood sugar balance, cardiovascular protection and healthy weight management.
Functional Foods & Beverages — Manufacturers add it into metabolic-support drink mixes, wellness shots and functional gummies to serve health-focused consumer groups.
Gut Health Products — Formulators combine it with prebiotics and synbiotics to create digestive comfort formulas and microbiome-support products, utilizing its natural antimicrobial strengths.
Sports and Active Nutrition — Developers apply it in body composition optimization, metabolic performance enhancement and post-workout recovery products for athletes and fitness enthusiasts.
Pet Nutrition — Veterinary supplement brands adopt it to maintain healthy blood glucose and balanced gut flora for companion animals, mainly dogs and cats.
Cosmetics & Personal Care — Skincare brands incorporate it into topical serums and creams. It regulates sebum secretion and relieves inflammation to improve acne-prone and sensitive skin conditions.
Berberine Hydrochloride vs. Other Metabolic Health Compounds
Most buyers compare Berberine Hydrochloride with mainstream metabolic and cardiovascular active ingredients during product development. To help you select the most suitable raw material for your formula, the table below clearly illustrates its unique advantages and core differences:
|
Compound
|
Key Features
|
Primary Applications
|
|---|---|---|
|
Berberine HCl
|
AMPK activator; multi-target: glucose + lipid + gut + liver
|
Metabolic, cardiovascular, gut, longevity
|
|
Chromium Picolinate
|
Insulin-sensitizer trace mineral; single pathway
|
Glucose balance, weight management
|
|
Alpha-Lipoic Acid
|
Antioxidant + glucose uptake support; limited lipid effect
|
Antioxidant, nerve health, glucose balance
|
|
Cinnamon Extract
|
Polyphenol blend; mild glucose and lipid effect
|
Glucose balance, antioxidant blends
|
|
Banaba Leaf Extract
|
Corosolic acid; mild glucose uptake support
|
Glucose balance, weight management
|
Key Benefits and Biological Functions
Multidimensional Metabolic Regulatory Properties
Berberine Hydrochloride delivers an extensive range of science-backed health advantages that consistently drive strong global market demand. Aside from its well-established metabolic and cardiovascular benefits, modern clinical research continuously uncovers new functional values in gut balance, liver protection and anti-aging support. As a result, natural ingredient brands widely regard Berberine Hydrochloride as a premium star component for high-end nutraceutical and functional food formulations.
First and foremost, this ingredient activates the AMPK signaling pathway and strengthens human insulin sensitivity. With this mechanism, it effectively stabilizes healthy fasting glucose, postprandial glucose and long-term HbA1c levels. According to multiple clinical trials, a daily supplementation of 500 mg two to three times per day delivers comparable metabolic improvement effects to conventional metformin in certain population groups.
In addition to blood sugar regulation, Berberine Hydrochloride optimizes overall lipid profiles. It actively reduces total cholesterol, LDL cholesterol and harmful triglyceride levels while it maintains healthy HDL cholesterol content. For this reason, formulators frequently integrate this ingredient into heart care, weight management and metabolic syndrome product lines.
Gut Health and Immune Modulation Capacity
Beyond metabolic support, Berberine Hydrochloride delivers prominent gut microecology regulation effects. It boosts the growth of beneficial intestinal strains such as Bifidobacterium and Akkermansia. Meanwhile, it inhibits the proliferation of conditional pathogens and repairs impaired intestinal barrier function. Ultimately, it greatly improves overall digestive comfort and intestinal health.
Furthermore, this natural compound exhibits broad-spectrum antimicrobial activity against bacteria, fungi, viruses and parasites. Simultaneously, it modulates NF-κB pathways and reduces excessive pro-inflammatory cytokines. This dual mechanism enables comprehensive immune defense and inflammatory balance for daily health maintenance.
Liver Protection, Weight Management and Longevity Potential
In terms of hepatic care, Berberine Hydrochloride stabilizes normal liver enzyme levels and reduces abnormal hepatic fat accumulation. It also defends liver cells against external toxin damage. Correspondingly, it perfectly matches consumer needs for liver detoxification and sub-health conditioning products.
When it comes to body management, clinical evidence confirms that continuous Berberine supplementation lowers body weight, BMI and waist circumference under reasonable lifestyle adjustments. Besides physical shaping, it optimizes leptin sensitivity, curbs unnecessary food cravings and helps users maintain healthy eating habits.
Last but not least, latest anti-aging research highlights its cellular protection value. It activates sirtuin longevity pathways and promotes mitochondrial biogenesis. Therefore, it serves as a powerful functional ingredient for longevity and healthy aging formulas.
Applications and Market Segments
Mainstream Health Product Applications
Berberine Hydrochloride features excellent water solubility, high safety and multi-target activity. Owing to these comprehensive strengths, it adapts to a wide variety of finished product forms and covers multiple mainstream health markets.
To begin with, it acts as a core raw material for dietary supplements including capsules, tablets, softgels and liquid extracts. These finished products focus on blood sugar balance, cardiovascular protection and scientific weight control. Secondly, functional food and beverage industries widely adopt it in metabolic support drink mixes, wellness shots and functional gummies for health-conscious consumers.
Thirdly, the gut health sector applies it in prebiotic and synbiotic compound formulas. It improves intestinal flora balance and enhances digestive comfort through its natural bacteriostatic properties. Moreover, sports nutrition brands utilize its metabolic optimization effects to develop body composition adjustment and post-workout recovery products for fitness crowds.
Emerging Cross-Industry Applications
Apart from human health products, Berberine Hydrochloride also expands into pet nutrition markets. Veterinary supplement brands add this ingredient to maintain stable blood glucose and balanced gut flora for companion animals. In addition, the cosmetic industry leverages its anti-inflammatory and sebum-regulating characteristics. It improves acne-prone and sensitive skin conditions in topical serums and skincare creams.
Berberine Hydrochloride vs. Other Metabolic Health Compounds
Product developers often compare different metabolic actives during formula design. For clearer differentiation, the following table summarizes the core features and applicable scenarios of mainstream ingredients:
|
Compound
|
Key Features
|
Primary Applications
|
|---|---|---|
|
Berberine HCl
|
AMPK activator; multi-target: glucose + lipid + gut + liver
|
Metabolic, cardiovascular, gut, longevity
|
|
Chromium Picolinate
|
Insulin-sensitizer trace mineral; single pathway
|
Glucose balance, weight management
|
|
Alpha-Lipoic Acid
|
Antioxidant + glucose uptake support; limited lipid effect
|
Antioxidant, nerve health, glucose balance
|
|
Cinnamon Extract
|
Polyphenol blend; mild glucose and lipid effect
|
Glucose balance, antioxidant blends
|
|
Banaba Leaf Extract
|
Corosolic acid; mild glucose uptake support
|
Glucose balance, weight management
|
Why Choose Our Berberine Hydrochloride?
Strict Production and High Purity Standard
Shaanxi Baisifu Biological Engineering focuses on high-purity natural plant extracts. To guarantee stable product quality, we select high-quality Berberis and Coptis raw materials at the best harvesting period. After precise screening, we adopt optimized acid-base extraction and recrystallization technologies. As a result, our finished Berberine Hydrochloride reaches HPLC purity above 97% steadily.
Beyond standard purity, we provide multiple grades including 97%, 98% and 99% to satisfy diverse formulation demands. Meanwhile, we support third-party independent testing for every batch to ensure consistent batch-to-batch stability.
Full-Service Support and Global Certification
In terms of global market accessibility, we hold complete ISO9001, ISO14001, KOSHER and HALAL certifications.These qualifications help clients smoothly launch products in European, American, Middle Eastern and Southeast Asian markets. Additionally, we develop exclusive CWS water-dispersible grades for beverage and liquid supplement development.
For customer service, we deliver samples within 3 working days and provide professional formula guidance and regulatory document support. Furthermore, flexible MOQ and customizable private packaging serve startup brands and large enterprises alike.
Quality Assurance and Certifications
Our factory operates under standardized quality management systems. To eliminate quality risks, we conduct comprehensive testing for each batch, covering HPLC identity confirmation, heavy metal screening, microbial inspection, pesticide residue detection and moisture analysis. Apart from strict internal control, our global valid certifications support cross-border sales. Finally, we provide complete CoA, MSDS and technical documents to simplify clients’ customs clearance and registration procedures.
Storage, Handling, and Shelf Life
In order to preserve maximum activity and stability, users need to store Berberine Hydrochloride in sealed and opaque containers. Specifically, keep the product away from high temperature, humid air and direct sunlight. Under qualified cool and dry conditions, the material maintains full efficacy for at least 24 months from the production date.
During daily use, seal the container immediately after sampling to avoid moisture absorption and oxidation discoloration. For liquid formula production, dissolve the powder in warm water or ethanol to prepare stable stock solution and avoid long-term light exposure.
Clinical and Preclinical Evidence
Berberine Hydrochloride possesses solid scientific research backing. First of all, multiple randomized, double-blind, placebo-controlled trials verify its metabolic improvement effects. A standard 500 mg dosage taken two to three times daily effectively improves fasting glucose, HbA1c and abnormal blood lipid indicators. Moreover, a landmark meta-analysis published by the American Journal of Cardiology proves its lipid-improving effects match mainstream statin therapy in specific crowds.
At the preclinical level, cell and animal experiments further confirm its multiple bioactivities. It delivers reliable antimicrobial, anti-inflammatory, liver-protective and anti-aging effects within safe supplementation ranges. Accordingly, it owns sufficient theoretical and practical basis for commercial health applications.
Regulatory Status and Safety Profile
In general, global mainstream regulatory institutions recognize Berberine Hydrochloride as a safe functional raw material. For instance, the US FDA lists Berberis plant ingredients as legal supplement materials. Similarly, the EU allows Berberis vulgaris extract in food supplements under transitional Novel Food rules.
In terms of safety performance, standard daily doses produce no obvious adverse reactions. Thus, the ingredient suits long-term daily health supplementation. Even so, pregnant women, lactating women and patients taking hypoglycemic medicines must consult professional doctors before use.
Frequently Asked Questions
What distinguishes Berberine Hydrochloride from Berberine base?
Both forms share the same core alkaloid structure. However, hydrochloride salt exhibits better water solubility, higher crystallization stability and better compression performance. For this reason, almost all supplement manufacturers prefer hydrochloride forms for finished production.
How does Berberine Hydrochloride compare to Metformin?
Both substances activate AMPK pathways and enhance insulin sensitivity. Evidently, Berberine achieves equivalent glucose and HbA1c improvement at conventional doses. Unlike synthetic drugs, it originates from pure botanical sources and fits natural health trends perfectly.
Can I combine Berberine Hydrochloride with other metabolic ingredients?
Yes, it features excellent compound compatibility. In practice, it synergizes well with chromium, alpha-lipoic acid, cinnamon extract, milk thistle and bitter melon. Because of its multi-target mechanism, it complements single-function ingredients and strengthens overall formula efficacy.
What is the recommended daily dosage for supplements?
Most clinical studies adopt 500 mg per serving, two to three times daily with meals. To cater to different product positioning, our technical team provides personalized dosage guidance based on target markets and regulatory rules.
Do you offer water-dispersible Berberine Hydrochloride?
We provide professional CWS cold-water soluble grades. Through food-grade micro-encapsulation technology, the powder disperses evenly in water without extra emulsifiers or solvents. This upgrade greatly expands its application in beverages and liquid supplements.
Contact and Order Information
If you plan to launch premium Berberine Hydrochloride products, our global sales team offers one-stop professional support. We currently serve clients across more than 50 countries and reply to all inquiries within one working day. Whether you need small R&D samples or large commercial shipments, we accommodate flexible purity grades, packaging solutions and delivery schedules.
Company: Shaanxi Baisifu Biological Engineering Co., Ltd.
Address: Room A, Baode Cloud Valley International, No. 52 Jinye 1st Road, Yanta District, Xi’an, Shaanxi, China
Certifications: ISO9001 | ISO14001 | KOSHER | HALAL
Core Products: Berberine Hydrochloride, Andrographolide, Camptothecin, Zeaxanthin, Caryophyllene, Coolants, Food Flavors
Markets Served: EU (27 countries), North America, Latin America, Caribbean, Southeast Asia, Middle East