Mangostine

Product Name	Mangostine
CAS	6147-11-1
Melting point	180-182°C
Boiling point	640.1±55.0 °C(Predicted)
Density	1.265± 0.06g /cm3(Predicted)
Storage conditions	2-8°C
Solubility	Soluble in methanol: 1mg/mL, transparent, light yellow
Morphological	Powder
Acidity coefficient (pKa)	7.22±0.20(Predicted)
Color	Light yellow to yellow
Purity	98%
Shelf life	2 years

Summarize

It is a kind of xanthone compound extracte from the plant bambusa sinensis. In addition, it is derive from the effective component of natural bamboos. And has the characteristics of safety, non-toxicity and a long history of consumption. Which provides the theoretical and application basis for the in-depth study of α-gogostin as a medicine.

Biological activity of Mangostine

Alpha-Mangostin (alpha-Mangostin) is a dixanthone with a wide range of biological activities. Such as, antioxidant, anti-allergic, anti-viral, antibacterial, anti-inflammatory and anti-cancer effects. So,It is an inhibitor of IDH1 mutant (IDH1-R132H) with a Ki value of 2.85 μM.

Chemical property

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. Derived from Guttiferae mangosteen shell, monahan fruit, mountain.

Use

Now,Baisfu Mangostine has the effect of treating diarrhea, malaria, anti-inflammatory, anti-ulcer, and anti-leukemia and septicemia.
For content determination/identification/pharmacological experiments, etc
Pharmacological effect: It has antioxidant, anti-inflammatory, antibacterial, anticancer and other pharmacological activities

In Vitro Study

Firstly,Mangostine (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H. But not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. Secondly,The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. And,alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells.

Then,Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Next,Alpha-mangostin also increases the levels of Bax (pro-apoptotic),cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). Alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H 2 O 2 -induced apoptosis of RPE cells. Finally,200 μM H 2 O 2 -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).