Nattokinase Powder — Premium Fermented Soybean Enzyme

High-Activity Fibrinolytic Enzyme for Cardiovascular Health, Circulation Support, and Blood Clot Prevention Formulations

 

Product Overview

Nattokinase powder derives from the traditional Japanese fermented soybean food natto, where Bacillus subtilis natto produces this potent fibrinolytic enzyme during fermentation. Specifically, nattokinase directly degrades fibrin — the protein meshwork that forms blood clots — through enzymatic hydrolysis, while also enhancing the body’s own plasminogen activator system. Furthermore, over 20 clinical studies including double-blind, placebo-controlled trials demonstrate nattokinase’s effectiveness in reducing blood pressure, lowering fibrinogen levels, and supporting healthy blood viscosity without the bleeding risks associated with pharmaceutical anticoagulants. Additionally, our nattokinase powder uses premium non-GMO soybeans fermented under precisely controlled conditions to maximize enzyme activity, measured in fibrinolytic units (FU).

Moreover, our advanced purification technology concentrates nattokinase while removing vitamin K2 (menaquinone-7) — an important feature for formulators targeting customers who take blood thinners and must avoid vitamin K interactions. Consequently, dietary supplement, functional food, and cardiovascular health brands worldwide select our nattokinase powder for its consistent enzymatic potency, excellent stability in capsule and tablet formats, and comprehensive regulatory documentation.

Key Specifications

Parameter	Specification
Product Name	Nattokinase Powder
Source	Non-GMO soybean (Glycine max) fermented with Bacillus subtilis natto
CAS Number	133876-92-3
Active Compound	Nattokinase — subtilisin-like serine protease enzyme
Enzyme Activity	2,000 – 40,000 FU/g (fibrinolytic units, customizable)
Available Forms	Fine powder, granulated powder, capsules, tablets, bulk packaging
Appearance	Cream-white to light yellow fine powder
Particle Size	95% pass 80 mesh
Solubility	Water-soluble at neutral to alkaline pH
pH Stability	Optimal activity at pH 7.0–9.0; stable at pH 5.0–10.0
Temperature Stability	Activity stable up to 50℃; short-term tolerance to 60℃
Moisture	≤ 5.0%
Heavy Metals	Pb ≤ 1.0 mg/kg, As ≤ 0.5 mg/kg, Hg ≤ 0.1 mg/kg, Cd ≤ 0.3 mg/kg
Microbiology	TPC ≤ 1,000 cfu/g; E. coli & Salmonella absent
Vitamin K2 Content	≤ 0.1 ppm (K2-removed grade); natural grade available upon request
Shelf Life	24 months stored cool, dry, away from light
Packaging	1 / 5 / 25 kg food-grade sealed bags or fiber drums with inner liner
Origin	China — Shaanxi Baisfu Bio-Engineering

 

Mechanism of Action & Health Benefits

Nattokinase delivers cardiovascular protection through four interconnected mechanisms. First, it directly hydrolyzes fibrin and fibrinogen, dissolving existing microthrombi and reducing blood viscosity. Second, it converts endogenous pro-urokinase to active urokinase, amplifying the body’s natural clot-dissolving capacity. Third, it degrades plasminogen activator inhibitor-1 (PAI-1), removing a key brake on fibrinolysis. Fourth, emerging research identifies nattokinase’s ability to degrade amyloid fibrils, opening potential applications in neurodegenerative disease prevention.

 

Cardiovascular Health & Blood Pressure Support

Supplement brands formulate nattokinase into capsules and tablets as a natural alternative to aspirin for daily cardiovascular maintenance. Furthermore, a landmark 2015 randomized controlled trial reported systolic blood pressure reductions of 5.55 mmHg and diastolic reductions of 2.84 mmHg with nattokinase supplementation over 8 weeks. Additionally, formulators combine nattokinase with CoQ10, hawthorn extract, and magnesium in comprehensive heart-health stacks.

 

Circulation Support & Deep Vein Thrombosis Prevention

Travel wellness brands and clinical nutrition companies target nattokinase for deep vein thrombosis (DVT) prevention during long-haul flights and prolonged sitting. Moreover, its fibrin-degrading ability supports healthy peripheral circulation in diabetics and elderly populations, where microcirculatory impairment often leads to complications. Consequently, circulation-focused supplement brands increasingly feature enteric-coated nattokinase capsules for targeted intestinal release.

 

Blood Viscosity & Anti-Platelet Aggregation

Nattokinase reduces blood viscosity through direct fibrinogen cleavage without impairing platelet function — a key distinction from aspirin and clopidogrel that appeals to consumers seeking gentler, food-derived alternatives. Furthermore, athletes and biohackers increasingly adopt nattokinase as part of optimized recovery and longevity protocols, driving rapid growth in direct-to-consumer supplement channels.

 

Neuroprotection & Amyloid Clearance

Breakthrough research demonstrates nattokinase’s ability to degrade amyloid-beta fibrils and tau protein aggregates associated with Alzheimer’s disease pathology. Additionally, improved cerebral blood flow from nattokinase’s fibrinolytic activity supports nutrient and oxygen delivery to brain tissue. Consequently, nootropic and longevity supplement innovators are actively exploring nattokinase in next-generation cognitive health formulations.

 

Why Choose Baisfu – Shaanxi Baisfu Bio-Engineering

Shaanxi Baisfu Bio-Engineering Co., Ltd. supplies premium enzyme and botanical ingredients to over 50 countries with manufacturing expertise spanning more than 15 years. Furthermore, our nattokinase production uses proprietary solid-state fermentation technology with authenticated Bacillus subtilis natto strains, non-GMO soybean substrate, and precisely controlled temperature, humidity, and aeration parameters that maximize fibrinolytic enzyme yield. Additionally, our GMP-compliant facility operates under ISO 9001, ISO 14001, KOSHER, HALAL, and Eurofins quality management systems, ensuring complete regulatory confidence for every shipment.

Moreover, our dedicated enzyme laboratory performs fibrin plate assay, casein digestion assay, and SDS-PAGE analysis on every batch to verify both enzymatic potency and protein purity. Consequently, clients receive thoroughly documented nattokinase powder that consistently meets labeled FU potency claims throughout the 24-month shelf life. Furthermore, our multilingual commercial team provides responsive support in English, Spanish, French, and Arabic.

• Consistent fibrinolytic activity verified by independent fibrin plate assay per batch
• Flexible enzyme activity from 2,000 to 40,000 FU/g
• K2-removed grade available for anticoagulant-compatible formulations (vitamin K2 ≤ 0.1 ppm)
• Non-GMO soybean substrate with full traceability documentation
• Free evaluation samples (30–50 g) for qualified buyers
• Short lead time: 5–10 business days for standard grades
• Complete documentation: COA, MSDS, TDS, GMO-Free, allergen statement, certificate of origin
• OEM / private label for enteric-coated capsules, tablets, and enzyme blends
• Regulatory experience with US FDA NDI, EU, TGA Australia, and ASEAN submissions

Quality Assurance & Enzyme Activity Testing

Every production batch undergoes comprehensive enzyme activity verification at our in-house analytical laboratory. Specifically, fibrin plate assay quantifies fibrinolytic activity in FU/g against a certified nattokinase reference standard, while casein digestion assay confirms proteolytic activity. Furthermore, SDS-PAGE and HPLC verify protein molecular weight and purity, and microbiological testing ensures sterility. Additionally, we perform accelerated stability studies at 40℃ / 75% RH to validate enzyme activity retention, and we retain reference samples from every production lot for 36 months.

Ordering & Delivery

We welcome both R&D sample requests and full-scale commercial orders. Typically, our sales team responds within 4 business hours with a detailed quotation, COA specimen, and confirmed delivery timeline. Furthermore, qualified buyers receive complimentary evaluation samples (30–50 g) to assess enzyme activity, solubility, and formulation compatibility before placing bulk orders.

Item	Details
Sample Policy	30–50 g free sample, freight collect
MOQ	1 kg standard; smaller R&D quantities available
Lead Time	5–10 days for stocked specs; 15–20 days for custom activity grades
Shipping Terms	EXW, FOB, CIF per buyer preference
Payment Terms	T/T, L/C, PayPal for sample orders
Storage	Cool (< 25℃), dry, away from light; reseal tightly after opening