Nobiletin

Nobiletin

CAS:478-01-3

Melting point:136.0to140.0°C
Boiling Point: 587.9±50.0°C(Predicted)
density: 1.244±0.06g/cm3(Predicted)
Storage conditions:Sealed in dry,Store in freezer, under -20°C
Solubility: Dissolved in DMSO (up to 10 mg/ml)
form:solid
color:White

Detailed Description

 

Nobiletin is a natural polymethoxylated flavonoid compound, mainly found in the peels of citrus fruits, such as tangerine peel, green peel and other Chinese medicinal materials. It has a unique chemical structure, consisting of a flavonoid nucleus and multiple methoxy groups. Nobiletin is a yellow crystalline powder, insoluble in water, and easily soluble in organic solvents such as ethanol and methanol. In traditional Chinese medicine, tangerine peel and other medicinal materials containing nobiletin are widely used. With the deepening of modern scientific research, the various biological activities of nobiletin have gradually been discovered and recognized.

Functions

Strong antioxidant capacity: Nobiletin has multiple methoxy groups, which give it strong antioxidant activity, can remove free radicals in the body, reduce the damage to cells caused by oxidative stress, and help prevent a variety of diseases related to oxidative damage, such as cardiovascular disease, cancer, neurodegenerative diseases, etc.
Significant anti-inflammatory properties: It can inhibit the release of inflammatory mediators and reduce inflammatory responses by regulating a variety of inflammatory signaling pathways. In the study of some inflammatory-related diseases, it has shown good anti-inflammatory effects and has potential therapeutic effects on inflammatory diseases such as arthritis and enteritis.
Multiple health benefits: Studies have found that Nobiletin also has multiple health benefits such as lowering blood lipids, lowering blood sugar, anti-tumor, antibacterial, and antiviral. For example, it can regulate lipid metabolism and reduce the levels of cholesterol and triglycerides in the blood; by affecting the insulin signaling pathway, it improves insulin resistance and helps control blood sugar; it has the effect of inhibiting proliferation and inducing apoptosis of a variety of tumor cells.

Applications

Medical field: Based on its multiple biological activities, nobiletin has broad application prospects in the medical field. It can be developed as a monomer drug for the treatment of cardiovascular diseases, diabetes, cancer and other diseases; it can also be used as an auxiliary therapeutic drug in combination with other drugs to enhance the therapeutic effect and reduce the side effects of drugs. In addition, it can also be used to develop anti-inflammatory, antibacterial, antiviral and other drugs.
Health care products industry: Since nobiletin has health care effects such as antioxidant, hypolipidemic, and hypoglycemic, it is often used in the research and development of health care products. It is made into capsules, tablets, oral liquids and other forms for consumers to take daily to enhance the body’s immunity, prevent chronic diseases, and play a role in health care.
Food industry: As a natural antioxidant and functional ingredient, nobiletin can be added to food to extend the shelf life of food and prevent food from oxidation and deterioration. At the same time, it can also be used to develop functional foods with specific health functions, such as adding to beverages, cakes, dairy products and other foods to increase the nutritional value and health care functions of food.
Cosmetic field: Because of its antioxidant and anti-inflammatory effects, nobiletin is used in cosmetics. It can be added to skin care products, such as creams, lotions, essences, etc., to help reduce the damage of free radicals to the skin, delay skin aging, improve skin inflammation, and enhance the skin’s barrier function.