Ranaconitine CAS: 1360-76-5

Ranaconitine

Product Name	Ranaconitine
Place of Origin	Shaanxi,China
Purity	≥98%
Appearance	Colorless needle crystal
Shape	Crystal
Category	Plant Extracts
MOQ	5 kg
Shelf Life	24 Months

Detailed Description

Ranaconitine is a traditional Chinese medicine (TCM) and has a broad spectrum of health effects, but with a narrow therapeutic window. It is important to identify both the therapeutic ingredients and the toxic components to better utilize this TCM. The present study investigated the cardiotoxicity of the selected compounds in Aconitum leucostomum Worosch. The effects of extract of A. leucostomum Worosch and the isolated compounds on cardiocardiomyocytes were evaluated in vitro. Five known compounds in this TCM, including three C18-diterpene alkaloids, lappaconitine ,

N-deacetyllappaconitine , and Ranaconitine , and two C19-diterpene alkaloids, delvestidine and anthranoyllycoctonine, were isolate from A. leucostomum Worosch. The cardiotoxicity of these components and extract fractions, as measured by lactate dehydrogenase release and apoptosis, was rank as follows, in descending order: delvestidine>anthranoyllycoctonine>pH 4 fraction>pH 8 fraction>aconitine>N-deacetyllappaconitine>Ranaconitine>lappaconitine. The cytotoxicity of these compounds was shown to be dose-dependent, with delvestidine and anthranoyllycoctonine being the two most toxic compounds to cardiomyocytes in our assays. These results provide a basis for future rational use of this TCM, reducing side effects while retaining therapeutic effects.

Applications of Ranaconitine

1. Agriculture field, as a natural plant pesticides that once touched the drug will suffocate;
2.Pharmaceutical field, matrine injection on the treatment of chronic persistent hepatitis have a good effect; can treat trichomonas vaginitis
3. Cosmetic field, it has good effect of anti-acne.

(1) Pharmaceutical as capsules or pills;
(2) Functional food as capsules or pills;
(3) Water-soluble beverages;
(4) Health products as capsules or pills.

Functions

1. Against HBV & HCV, can treat chronic hepatitis;
2. Anti cancer;
3. Can use as pesticide;
4. Against pathogen;
5. Anti-allergy and anti-inflammation. it can regulate immunity and increase white blood cell.