Caryophyllene oxide is a naturally occurring sesquiterpene and the oxidized form of beta-caryophyllene. It is a major component in the essential oils of cloves, rosemary, and cannabis, where it is notably the compound that drug-sniffing dogs are trained to detect. This compound contributes a characteristic woody, spicy aroma. Beyond its scent, it is the subject of significant scientific research due to its promising biological activities. Studies have shown that caryophyllene oxide possesses potent anti-inflammatory, antimicrobial, and antifungal properties. Furthermore, research indicates it may have anti-cancer potential by demonstrating an ability to induce apoptosis in certain cancer cells, making it a compound of great interest in pharmacology and natural medicine.